Detectable HBV DNA in plasma but no HBV drug resistance in HIV/HBV co-infected patients on tenofovir-containing antiretroviral therapy

A/Prof. Joe Sasadeusz

Tenofovir (TDF) is effective in suppressing HIV and HBV replication in HIV/HBV co-infection. HBV DNA can persist in some individuals on TDF-containing combination antiretroviral therapy (ART) but HBV resistance to TDF has not been reported to date. We initiated this study to identify novel HBV mutations in HIV-HBV co-infected individuals receiving TDF, and determine risk factors associated with detectable HBV DNA on TDF. 


Disclosure of Interest Statement: We acknowledge funding from Gilead Sciences.
2013 Australasian HIV & AIDS and Sexual Health Conference, 21-25 October, Darwin - Australia
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 The Australasian Society for HIV Medicine 

Joe Sasadeusz
Joe Sasadeusz
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VideoDetectable HBV DNA in plasma but no HBV drug resistance in HIV/HBV co-infected patients on tenofovir-containing antiretroviral therapyJoe Sasadeusz15'12"
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A/Prof. Joe Sasadeusz

MB BS, FRACP, PhD. Dr Sasadeusz is a Senior physician at the hepatitis clinic at The Royal Melbourne Hospital as well as HIV-hepatitis co-infection clinics at the Alfred Hospital and Melbourne Sexual Health Centre.  Dr Sasadeusz also has an attachment to the Bone Marrow Transplant Service at The Royal Melbourne Hospital where he has a specific interest in viral infections in bone marrow transplant recipients. 

Co-authors: J. Audsley1, 2, A. Avihingsanon3, G. Matthews4, S. Bowden5, M. Littlejohn5, L. yuen5, S. Locarnini5, SR. Lewin1, 2. 1- Department of Infectious Diseases, Monash University. 2- Department of Infectious Deseases, The Alfred Hospital. 3- HIV-NAT Research Collaboration, Thailand, 4- The Kirby Institute. 5- VIDRL, North Melbourne, Burnet Institute.
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